About the authorPaul VegasShare the loveHave your say Man City boss Guardiola: Gallardo deserved FIFA nominationby Paul Vegas20 days agoSend to a friendShare the loveManchester City boss Pep Guardiola is full of praise for Marcelo Gallardo.The River Plate coach is being linked with Ernesto Valverde’s job at Barcelona.And Pep told TNT: “What Gallardo has done with River is incredible, at the level of results, giving them consistency every year despite the fact that players leave and he continues to be … there are things that I cannot explain much, we are nominated as three coaches for the best of the year and he is not there. “It seems that there is only Europe, I do not understand how he is not nominated and not only for a year also for what he has done, I hope one day I can face one of his teams, it would be very nice.”
May 16, 2018The 5th Annual Form Arcosanti creative retreat and music festival was held over the weekend of May 11th – 13th. Check out the beautiful pictures of the festivities. (photos by Sue Kirsch)
13Feb Glenn invited to join Hispanic caucus in Lansing Rep. Gary Glenn, R-Midland, left, and Michigan Legislative Hispanic Caucus chairman Rep. Harvey Santana, D-Detroit. Both men share the bond of being veterans. Glenn served in the U.S. Army Reserves and National Guard, and Santana was a U.S. Navy rescue swimmer.Lansing, Mich. — Rep. Gary Glenn, R-Midland, on Thursday joined the bipartisan Michigan Legislative Hispanic Caucus at the invitation of newly-elected caucus chairman Rep. Harvey Santana, D-Detroit and vice-chairman Rep. Bruce Rendon, R-Lake City.Glenn is not Hispanic, but the caucus by-laws state that “MLHC is committed to diversity and actively seeks to elect and recruit individuals from all segments of the population as officers, committee chairs, and members.”Santana said Friday he is “very excited and encouraged to have Rep. Glenn as a member. His experience will add tremendous value to the overall discussion of Hispanic economic prosperity. I look forward to listening to his views on the economy and how we can all participate in the American dream.”Glenn commended Santana for his leadership in convening the caucus and said “Harvey and I will focus on the common values that unite us regardless of ethnicity or party. President Kennedy correctly observed that ‘a rising tide lifts all boats,’ and all legislators should be committed to policies that raise the tide of economic opportunity in Rep. Santana’s district as much as in our own.”For example, Glenn said he will work to win caucus support for legislation to allow implementation of the Mackinac Center for Public Policy’s proposed Universal Tuition Tax Credit, which would “empower parents of all income levels, of all races or ethnic backgrounds, in all communities, to choose the best and safest schools for their children.”Santana said the caucus will focus on issues of common concern to Hispanics and all citizens including taxes, small business development, infrastructure investment, public education (K-12, college, and vocational), criminal justice, agriculture, housing, employment, and health care. Glenn and Santana have already agreed, once the weather improves, to host each other for a tour of their respective legislative districts.“Rep. Santana and I have the same title, but for him, the job description includes, for example, being called to personally intervene to stop violence between rival gangs,” Glenn said. “Obviously, we’re blessed that that’s not been part of the job description in Midland and rural Bay counties, so visiting each other’s district and witnessing the many differences will be educational and enlightening for both of us.“It’s about understanding, literally and figuratively, where the other guy’s coming from, and hopefully crafting bipartisan solutions based on understanding our differences that can then unite us in the task — without government dictating or guaranteeing equal outcomes – of ensuring everyone has equal opportunity to make a better life for themselves and their families.”Santana’s 9th House District is comprised of northwest Detroit and part of the city of Dearborn.The 98th House District represented by Glenn is comprised of the city of Midland and six suburban and rural townships in Midland County, plus the cities of Auburn, Linwood, and Pinconning and seven rural townships in Bay County.The caucus is also tentatively planning to hold a town hall meeting in May in Saginaw hosted by Rep. Vanessa Guerra, D-Saginaw.According to the U.S. Census, Hispanics comprise 8 percent of the population in Saginaw County and 4.9 percent in Bay County, both higher than the 4.7 percent statewide, while only 2.4 percent of Midland County residents are of Hispanic origin. Categories: Glenn News,Glenn Photos
Categories: Hernandez News,News 02Oct Rep. Hernandez Honored During Hispanic Heritage Month PHOTO INFORMATION: (from left to right) MI-ALMA Board of Directors member Larry Arreguin, MI ALMA-Board of Directors member Saturnino “Nino” Rodriguez, state Rep. Shane Hernandez and former state Rep. Lee Gonzales.LANSING – State Representative Shane Hernandez (R-Port Huron) was honored last week by the Michigan Alliance of Latinos Moving Towards Advancement as part of their Hispanic Heritage Month celebrations.Hernandez, a freshman legislator who was named the “most conservative” member of the house for 2017 by MIRS news, stressed that he considers himself an American first:“My father taught us to consider ourselves Americans first,” said Hernandez. “However, I am very proud of my family heritage.”Representative Hernandez father, Salvador Hernandez Jr., worked his way up from general laborer to boiler operator at the Croswell pickle factory. He instilled in his children a ferocious worth ethic and deep love of the United States Constitution. Values he still holds sacred.
Drug interactions, including drug-drug interactions (DDIs) and drug-food constituent interactions (DFIs), can trigger unexpected pharmacological effects, including adverse drug events (ADEs), with causal mechanisms often unknown. However, current prediction methods do not provide sufficient details beyond the chance of DDI occurrence, or require detailed drug information often unavailable for DDI prediction. Journal information: Proceedings of the National Academy of Sciences Figure 1. Overall scheme of Deep DDDI and prediction of food constituents that reduce the in vivo concentration of approved drugs. Credit: Korea Advanced Institute of Science and Technology A new method of modeling drug-target interactions fixes a detrimental bias of past techniques Explore further More information: Deep learning improves prediction of drug–drug and drug–food interactions, Proceedings of the National Academy of Sciences (2018). 10.1073/pnas.1803294115 To tackle this problem, Dr. Jae Yong Ryu, Assistant Professor Hyun Uk Kim and Distinguished Professor Sang Yup Lee, all from the Department of Chemical and Biomolecular Engineering at Korea Advanced Institute of Science and Technology (KAIST), developed a computational framework, named DeepDDI, that accurately predicts 86 DDI types for a given drug pair. The research results were published online in Proceedings of the National Academy of Sciences (PNAS) on April 16, 2018, which is titled “Deep learning improves prediction of drug-drug and drug-food interactions.”DeepDDI takes structural information and names of two drugs in pair as inputs, and predicts relevant DDI types for the input drug pair. DeepDDI uses deep neural network to predict 86 DDI types with a mean accuracy of 92.4% using the DrugBank gold standard DDI dataset covering 192,284 DDIs contributed by 191,878 drug pairs. Very importantly, DDI types predicted by DeepDDI are generated in the form of human-readable sentences as outputs, which describe changes in pharmacological effects and/or the risk of ADEs as a result of the interaction between two drugs in pair. For example, DeepDDI output sentences describing potential interactions between oxycodone (opioid pain medication) and atazanavir (antiretroviral medication) were generated as follows: “The metabolism of Oxycodone can be decreased when combined with Atazanavir”; and “The risk or severity of adverse effects can be increased when Oxycodone is combined with Atazanavir”. By doing this, DeepDDI can provide more specific information on drug interactions beyond the occurrence chance of DDIs or ADEs typically reported to date.DeepDDI was first used to predict DDI types of 2,329,561 drug pairs from all possible combinations of 2,159 approved drugs, from which DDI types of 487,632 drug pairs were newly predicted. Also, DeepDDI can be used to suggest which drug or food to avoid during medication in order to minimize the chance of adverse drug events or optimize the drug efficacy. To this end, DeepDDI was used to suggest potential causal mechanisms for the reported ADEs of 9,284 drug pairs, and also predict alternative drug candidates for 62,707 drug pairs having negative health effects to keep only the beneficial effects. Furthermore, DeepDDI was applied to 3,288,157 drug-food constituent pairs (2,159 approved drugs and 1,523 well-characterized food constituents) to predict DFIs. The effects of 256 food constituents on pharmacological effects of interacting drugs and bioactivities of 149 food constituents were also finally predicted. All these prediction results can be useful if an individual is taking medications for a specific (chronic) disease such as hypertension or diabetes mellitus type 2.Distinguished Professor Sang Yup Lee said, “We have developed a platform technology DeepDDI that will allow precision medicine in the era of Fourth Industrial Revolution. DeepDDI can serve to provide important information on drug prescription and dietary suggestions while taking certain drugs to maximize health benefits and ultimately help maintain a healthy life in this aging society.” This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Deep learning predicts drug-drug and drug-food interactions (2018, April 18) retrieved 18 July 2019 from https://phys.org/news/2018-04-deep-drug-drug-drug-food-interactions.html Provided by The Korea Advanced Institute of Science and Technology (KAIST)
Explore further The future of renewable infrastructure is uncertain without good planning Why do people oppose these projects? One of the reasons is that stakeholders—local, regional and national governments, industry, environmental organizations and local residents—often feel their views and concerns aren’t being considered. To address the problem, the EU-funded project INSPIRE-GRID created several tools that allow all voices to be heard in the grid expansion planning and approval process. The project’s solution for increased stakeholder engagement has the potential to enable better conflict management and an expedited permit process.Tools for information and collaborationThe project team’s challenge was to help citizens provide informed opinions on complex matters by finding ways to bridge the information gap between power grid experts and the general public. Their solution to this challenge was to combine methods that facilitate decision-making with state-of-the-art tools that facilitate collaboration between all stakeholders.One of these tools, the geographic information system (GIS) web interface, makes it possible for local residents to visualize a power line’s possible routes and submit their views on them. A GIS was used in the planning of Swiss transmission line paths and of a power line transmitting wind-generated energy from the north to the south of Germany.Other INSPIRE-GRID tools deal with the difficulty of communicating a project’s expected benefits, which may not always be easily visible at local level. The project’s life-cycle assessment tool helps stakeholders to see the environmental impacts of future power lines. It also explains the reasons why a grid extension may be needed, for example to link renewable energy to the system or to reduce power interruptions and blackouts. Since the project’s end in 2017, such tools have already been used in a real-world environment.An INSPIRE-GRID (Improved and eNhanced Stakeholders Participation In Reinforcement of Electricity Grid) poster published on the ResearchGate website provides some promising conclusions about stakeholder engagement in future grid expansion projects. They state that “[e]arly, fair and trustworthy involvement of stakeholders can increase acceptance” of new grid projects. They also mention “careful selection of stakeholder engagement methods” and the use of “participatory decision-making methods to generate more inclusive decisions” as important factors to be considered. One thing is for sure, using these methods can only be a positive stepping stone to a more energy-efficient and low-carbon economy. Citation: Novel tools bridge the information gap between citizens and electricity grid operators (2019, June 6) retrieved 17 July 2019 from https://phys.org/news/2019-06-tools-bridge-gap-citizens-electricity.html It’s generally agreed that a low-carbon economy is important if we’re to combat climate change. One obvious way to do this is to modernize our current power transmission grids so that we can make electricity more secure, affordable and sustainable. However, while this may seem straightforward in theory, in reality things aren’t always so simple. New grid projects often face strong opposition by the organizations and communities they affect. When such opposition is added to the lengthy process of obtaining the necessary permits that can last up to 10 years, many of these projects are delayed or even canceled. More information: INSPIRE-GRID project website: www.inspire-grid.eu/Stakeholder participation in the development of the electricity grid: the INSPIRE-Grid project: www.researchgate.net/publicati … INSPIRE-Grid_project Credit: CC0 Public Domain Provided by CORDIS This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.