Water polo: Win for H.-W. a squeeze

first_imgThat’s the type of shot the Harvard-Westlake of Studio City girls’ water polo team had to make in an 11-8 win against Burbank in the second round of the Southern Section’s Div. IV playoffs. The Bulldogs (21-8) made the Wolverines (16-8) work for their goals with a stingy defense that held Harvard-Westlake’s potent offense to three in the first quarter. Burbank pressed the Wolverines’ attackers, trying to limit shooting angles. Harvard-Westlake used a zone defense to keep the Bulldogs from spreading the ball around. Despite the defensive strategies, both teams were able to open up the scoring in the second quarter, which featured 10 goals, including Moody’s shot that just got past Singleton. “They had really a good corner shot,” said Singleton, who finished the game with 10 saves. “They really didn’t have anything different in terms of shot power that we haven’t seen before, but I think they had one girl who’s got some past me because, I think she’s a lefty. I haven’t seen a lefty shooter this season.” Singleton was referring to driver Nadia Dan, who led Harvard-Westlake with six goals. Wendy Perez added three goals. Ani Shirinian led the Bulldogs with three goals, while Jordan Meir added two. Hannah Moody’s shot skid off the water and squeezed beneath Lachee Singleton’s arm into the left lower corner of the goal Friday. Moody’s shot didn’t come with a lot of power, but its location worked against the Burbank goalkeeper. center_img Burbank kept pace with the Wolverines and tied the game at four, midway through the second quarter. “I didn’t expect it to be this tight,” said Larry Felix, the Wolverines’ coach. “We were a bit tight there at the start, this being the first CIF game for some of my girl,but they picked it up in the third (quarter).” [email protected] (818) 713-3607 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!last_img read more


first_imgTory as far as the eye can see!The stunning setting of Tory Island will provide the perfect backdrop for a 10K walk in aid of a very special cause next Saturday.The walk, from East Town to West Town, will take place for the Irish Guide Dogs on August 9th.Tory’s famous lighthouseIf you have never visited Tory Island then this is your perfect chance. From boasting its very own King in the affable Patsy Dan Rodgers to the Tory Island Painters, the island is a remarkable piece of the Donegal landscape which not enough of us see.The cost of the walk is €10 per adult, €5 per child and €20 per family.Registration is at 12.45pm at the Harbour Hotel and the walk commences at 1.30pm.A reduced boat fare of just €20 return is available for walkers. There will also be refreshments and a session in the Harbour View Hotel which is now run by the former lighthouse keeper Sean Doherty and his family.If you have always wanted to visit Tory then now is your chance to do so for a good cause.For more details ring Bernie on 086 603 9343 or email [email protected] WHY NEXT WEEKEND IS THE PERFECT EXCUSE TO VISIT TORY ISLAND was last modified: August 5th, 2014 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:Guide Dogspatsy dan rodgersTory HotelTory IslandWalk for th Blindlast_img read more

New improved mouse model could revolutionize bone metastasis research

first_imgJul 30 2018Researchers at Tokyo Institute of Technology propose an improved mouse model that could revolutionize bone metastasis research. Their method, which involves injecting cancer cells via the so-called caudal artery in the mouse tail, overcomes many limitations of traditional mouse models. The new model could thus open a new chapter in the development of therapeutic strategies for bone metastasis and cancer progression.In a study published in Nature Communications, a group of researchers led by Takahiro Kuchimaru and Shinae Kondoh of Tokyo Institute of Technology (Tokyo Tech) present a mouse model that could greatly improve understanding of the underlying biology of bone metastasis.It is widely known that metastasis — the spread of cancer cells from a primary tumor to other parts of the body — is one of the main causes of cancer mortality in humans. Bone metastasis commonly occurs when cancer cells spread to the bone from tumors originating, for example, in the prostate, breast, lung and kidney.Experimental mouse models provide vital clues as to how cancer cells proliferate and how treatments could be developed. For the last 20 years, a model based on intracardiac (IC) injection has been considered the “gold standard” for inducing bone metastasis. This model involves injecting cancer cells directly into the left ventricle of the mouse heart. It requires a high degree of technical expertise, and even when performed successfully, the number of cancer cells that can be injected at any one time is limited. Another drawback is that the IC model tends to be more suitable for studying cancer cell lines that have a relatively high metastatic ability, ruling out analysis of “weaker” cancer cell lines.Related StoriesStudy discusses beneficial effects of antibody therapy that targets sclerostinCommon antibacterial agent may be bad news for bone healthStudy reveals dual effects of new osteoporosis therapy on bone tissueIn contrast, the new method developed by Kondoh’s group involves injecting cancer cells via the caudal artery (CA) in the mouse tail — a procedure that can be performed much more easily as the artery is visible on the body surface. (See Figures 1 and 2.) This method allows researchers to inject a larger number of cancer cells without causing acute death: In the present study, around one million cells were injected without any acute death. Moreover, the new method provides a new way of studying cancer cell lines with low bone metastatic potential.The researchers emphasize that the CA model predominantly ensures that bone metastasis develops in the hind limbs with much higher efficiency.Using bioluminescence (BL) imaging, the team was able to detect bone metastasis just five to twelve days after CA injection of all cell lines examined.”Overall, the results demonstrated that CA injection provides a reliable method to develop bone metastasis by increasing the delivery efficiency of a wide variety of cancer cell lines to the bone marrow of the hind limbs in mice,” they say.In addition, the CA model enables scientists to monitor the progression of bone metastasis over a longer period of time compared with the IC model due to reduced incidence of lethal metastasis in other organs. This represents a big step forward for investigating cancer cell dormancy and reactivation in greater depth.The researchers conclude: “Our model may open a new avenue for understanding the bone metastatic processes and development of drugs preventing bone metastasis and recurrence.” Source:https://www.titech.ac.jp/english/last_img read more